曹成喜教授

  • 电话:021-3420 5820

  • 邮箱:cxcao@sjtu.edu.cn

研究方向

  • POCT诊断技术,糖尿病地贫诊断技术,自由流电泳技术,界面电泳与传感

工作经历

  • 1988.7-1999.8:皖南医学院法医学系法医、主检法医、讲师与副教授
  • 2001.1-2002.6:中国科学技术大学化学系:副教授
  • 2002.7-2004.7:上海交通大学生物工程系副教授
  • 2004.8-2016.7:上海交通大学生物工程系教授
  • 2016.-现在:上海交通大学感知学院长聘教授

教育经历

  • 1999.9-2020.12: 中国科学技术大学理学博士学位

荣誉

  • 2000年:中国科学院院长奖学金
  • 2013年:上海交通大学优秀科研团队
  • 2016年:上海交通大学长聘教授", 
  • 2020年:入选斯坦福大学全球2%顶级科学家

研究成果

30年来提出了系统的反应界面(MRB)电泳物理模型与传感理论,发表论文130余篇。

发展了基于MRB的聚焦电泳动(IEF)力学理论,解决了IEF一系列基础科学问题,研制了微阵列IEF成套技术设备与关键材料部件,并用于临床检验与生物制药等领域。

发展了基于IEF的大型自由流电泳(FFE)技术设备、数字仿真、关键材料试剂,并用于病毒疫苗、蛋白药物、细胞与微生物等制备性分离纯化。

FFE技术装备与仿真模拟已荣获2013国际工业博览会高效展区优秀展品奖、2013国际高新技术展览会优秀产品奖、2020上海交通大学虚拟仿真实验教学优秀项目。

在Biosens. Bioelectrons., Sens. Accuats. B和Lab Chip等发表论文180余篇(Q1区论文80余篇),申请获得发明专利60项。国际会议邀请报告30余场,国内200余场。

学术兼职

  • 《基础电泳装置》国家标准小组成员
  • 清华大学国家重大科学仪器设备专项监理组成员
  • 同济大学国家重大科学仪器设备专项技术委员会委员
  • 上海市第六人民医院兼职教授
  • 上海交通大学微生物代谢国家重点实验室教授
  • 亚太生物分离分析APCE2017国际会议主席
  • 国际微分离会议MSB2021(美国波士顿)电泳分会主席 
  • 中国生化与分子生物学会蛋白质组学专业委员会常务委员
  • 中国卫生文化协会医工融合分会常务委员

项目情况

先后承担30多项国家课题等,包括8项NSFC课题、1项重点课题、国家重大科学仪器研制项目2项(科技部和NSFC各1项)、1项973子课题、1项863项目课题、1项国家重大新药创制子课题、1项卫生部课题、1项上海重大仪器项目、电泳产业化项目1项。

代表论文

  • J. Y. Dong,S. Li,H. Y. Wang,Q. H. Meng,L. Y. Fan,H. Y. Xie,C. X. Cao,* W. B. Zhang,* A simple boric acid-based fluorescent focusing for sensing of glucose and glycoprotein via multipath moving supramolecular boundary electrophoresis chip,Anal. Chem.,2013,85,5884-5891.

  • H. Y. Wang,Y. T. Shi,J. Yan,J. Y. Dong,S. Li,H. Xiao,H. Y. Xie,L. Y. Fan,* C. X. Cao* A retardation signal for fluorescent determination of total protein content via rapid and sensitive chip moving reaction boundary electrophoretic titration,Anal. Chem.,2014,86,2888-2894. 

  • Q. H. Meng,* T. Han,G. Q. Wang,N. Zheng,C. X. Cao,* S. A. Xie,Preparation of a natural dye doped ormosil coating for the detection of formaldehyde in the optical gas sensor,Sens. Actuats. B,2014,196,238–244. 

  • Z. Liu,L. Y. Fan,H. Xiao,* C. X. Cao,* Multiple covalent crosslink soft hydrogels for bioseparation,Chem. Commun.,2016,52,3247-3250.

  • X. Zhang,Y. R. Cao,H. Xiao,X. P. Liu,S. R. Liu,Q. H. Meng,L. Y. Fan,* C. X. Cao,* Leverage principle of retardation signal in titration of double protein via chip moving reaction boundary electrophoresis,Biosens. Bioelectrons.,2016,77,284-291. 

  •  Z. Liu,L. Y. Fan,H. Xiao,* C. X. Cao,* Multiple covalent crosslink soft hydrogels for bioseparation,Chem. Commun. ,2016,52,3247-3250. 

  • R. Zhong,H. Y. Xie,Q. Zhang,S. Jahan,H. Xiao,L. Y. Fan,C. X. Cao,* Enzyme catalysis-electrophoresis titration for multiplex enzymatic assay via moving reaction boundary chip,Lab Chip ,2016,16,3538-3547.

  • S. Jahan,Q. Zhang,A. Pratush,H. Y. Xie,H. Xiao,L. Y. Fan,C. X. Cao,* In-vial temperature gradient headspace single drop microextraction designed by multi-physics simulation,Anal. Chem.,2016,88,10490–10498. 

  • Y. C. He,F. Z. Kong,L. Y. Fan,J. Y. Wu,X. P. Liu,J. Li,Y. Sun,Q. Zhang,Y. Yang,X. J. Wu,H. Xiao,* C. X. Cao,* Preparation of intact mitochondria using free-flow isoelectri c focusing with post-pH gradient sample injection for morphological,functional and proteomics studies,Anal. Chim. Acta,2017,982,200-208.

  • Z. Liu,Z. J. Xiao,L. Y. Fan,H. Xiao,* C. X. Cao,* An ionic coordination hybrid hydrogel for bioseparation,Chem. Commun.,2017,53,5842-5845. 

  • W. L. Li,Q. Zhang,H. Kong,X. P. Liu,M. I. Khan,A. Wahid,S. Saud,Hua Xiao,C. X Cao,* L. Y. Fan,* A simple chip electrophoresis titration of neutralization boundary with EDTA photocatalysis for distance-based sensing of melamine in dairy product,Anal.Chem.,2018,90,6710-6717. 

  • X. Y. Cao,F. Z. Kong,Q. Zhang,W. W. Liu,X. P. Liu,G. Q. Li,R. Zhong,L. Y. Fan,* H. Xiao,C. X. Cao,* iPhone-imaged and cell-powered electrophoresis titration chip for the alkaline phosphatase assay in serum by the moving reaction boundary,Lab Chip,2018,18,1758-1766. 

  • F. Z. Kong,S. Jahan,R. Zhong,X. Y. Cao,W. L. Li,Y. X. Wang*,H. Xiao,W. W. Liu*,C. X. Cao*,Electrophoresis titration model of a moving redox boundary chip for a point-of-care test of an enzyme-linked immunosorbent assay,ACS Sens.,2019,4,126–133.

  • M. I. Khan,Q. Zhang,S. Saud,S. R. Liu,Y. X. Wang,H. Kong,C. H. Wang,A. Uzzaman,L. Y. Fan,H. Xiao,C. X. Cao*,Portable electrophoresis titration chip model for sensing of uric acid in urine and blood by moving reaction boundary,Sens. Actuats. B,2019,286,9-15. 

  • C. H. Wang,Q. Zhang,X. P. Liu,G. Q. Li,H. Kong,M. I. Khan,H. Xiao,Y. X. Wang*,W. W. Liu*,C. X. Cao*,Double inner standard plot model of electrophoresis titration chip for portable and green protein content assay of milk,Lab Chip,2019,19,484–492. 

  • Q. Zhang,W. W. Liu,M. Idrees Khan,C. H. Wang,G. Q. Li,H. Xiao,Y. X. Wang,* C. X. Cao,* Facile Counting of Ligands Capped on Nanoparticles via a Titration Chip of Moving Reaction Boundary Electrophoresis,Anal. Chem.,2019,91,7500-7504.

  • H. Kong,W. W. Liu,W. Zhang,Q. Zhang,C. H. Wang,M. I. Khan,Y. X. Wang,* L. Y. Fan,* C. X. Cao,* A Facile,Rapid and Low-cost Electrophoresis Titration of Thrombin by Aptamer-linked Magnetic Nanoparticle and Redox Boundary Chip,ACS App. Mat. Inter.,2019,11,29549-29556. 

  • X. T. Jiang,S. Liu,Y. Zhang,A. Sohai,C. X. Cao,* P. Wang,* H. Xiao,* Free-flow Isoelectric Focusing for Comprehensive Separation and Analysis of Human Salivary Microbiome for Lung Cancer,Anal. Chem.,2020,92,12017-12025.

  • X. J. Wu,Q. H. Meng,Q. Zhang,L. Y. Fan,* H. Xiao,C. X. Cao*,Fluorescent Speed Sensing Model and Boronic Complex Probe for Glycoprotein Assay via a Supramolecular Boundary Electrophoresis,Sens. Actuats. B,2020,309,127773. 

  • L. Chen,Q. Zhang,W. W. Liu,H. Xiao,X. P. Liu,L. Y. Fan,Y. X. Wang,H. G. Li,* C. X. Cao,* Facile and sensitive miRNA electrophoresis titration of moving reaction boundary chip with label-free non-enzymatic amplification,Biosens. Bioelectrons.,2020,170,112676.