曹成喜教授
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电话:021-3420 5820
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邮箱:cxcao@sjtu.edu.cn
研究方向
- POCT诊断技术,糖尿病地贫诊断技术,自由流电泳技术,界面电泳与传感
工作经历
- 1988.7-1999.8:皖南医学院法医学系法医、主检法医、讲师与副教授
- 2001.1-2002.6:中国科学技术大学化学系:副教授
- 2002.7-2004.7:上海交通大学生物工程系副教授
- 2004.8-2016.7:上海交通大学生物工程系教授
- 2016.-现在:上海交通大学感知学院长聘教授
教育经历
- 1999.9-2020.12: 中国科学技术大学理学博士学位
荣誉
- 2000年:中国科学院院长奖学金
- 2013年:上海交通大学优秀科研团队
- 2016年:上海交通大学长聘教授",
- 2020年:入选斯坦福大学全球2%顶级科学家
研究成果
30年来提出了系统的反应界面(MRB)电泳物理模型与传感理论,发表论文130余篇。
发展了基于MRB的聚焦电泳动(IEF)力学理论,解决了IEF一系列基础科学问题,研制了微阵列IEF成套技术设备与关键材料部件,并用于临床检验与生物制药等领域。
发展了基于IEF的大型自由流电泳(FFE)技术设备、数字仿真、关键材料试剂,并用于病毒疫苗、蛋白药物、细胞与微生物等制备性分离纯化。
FFE技术装备与仿真模拟已荣获2013国际工业博览会高效展区优秀展品奖、2013国际高新技术展览会优秀产品奖、2020上海交通大学虚拟仿真实验教学优秀项目。
在Biosens. Bioelectrons., Sens. Accuats. B和Lab Chip等发表论文180余篇(Q1区论文80余篇),申请获得发明专利60项。国际会议邀请报告30余场,国内200余场。
学术兼职
- 《基础电泳装置》国家标准小组成员
- 清华大学国家重大科学仪器设备专项监理组成员
- 同济大学国家重大科学仪器设备专项技术委员会委员
- 上海市第六人民医院兼职教授
- 上海交通大学微生物代谢国家重点实验室教授
- 亚太生物分离分析APCE2017国际会议主席
- 国际微分离会议MSB2021(美国波士顿)电泳分会主席
- 中国生化与分子生物学会蛋白质组学专业委员会常务委员
- 中国卫生文化协会医工融合分会常务委员
项目情况
先后承担30多项国家课题等,包括8项NSFC课题、1项重点课题、国家重大科学仪器研制项目2项(科技部和NSFC各1项)、1项973子课题、1项863项目课题、1项国家重大新药创制子课题、1项卫生部课题、1项上海重大仪器项目、电泳产业化项目1项。
代表论文
J. Y. Dong,S. Li,H. Y. Wang,Q. H. Meng,L. Y. Fan,H. Y. Xie,C. X. Cao,* W. B. Zhang,* A simple boric acid-based fluorescent focusing for sensing of glucose and glycoprotein via multipath moving supramolecular boundary electrophoresis chip,Anal. Chem.,2013,85,5884-5891.
H. Y. Wang,Y. T. Shi,J. Yan,J. Y. Dong,S. Li,H. Xiao,H. Y. Xie,L. Y. Fan,* C. X. Cao* A retardation signal for fluorescent determination of total protein content via rapid and sensitive chip moving reaction boundary electrophoretic titration,Anal. Chem.,2014,86,2888-2894.
Q. H. Meng,* T. Han,G. Q. Wang,N. Zheng,C. X. Cao,* S. A. Xie,Preparation of a natural dye doped ormosil coating for the detection of formaldehyde in the optical gas sensor,Sens. Actuats. B,2014,196,238–244.
Z. Liu,L. Y. Fan,H. Xiao,* C. X. Cao,* Multiple covalent crosslink soft hydrogels for bioseparation,Chem. Commun.,2016,52,3247-3250.
X. Zhang,Y. R. Cao,H. Xiao,X. P. Liu,S. R. Liu,Q. H. Meng,L. Y. Fan,* C. X. Cao,* Leverage principle of retardation signal in titration of double protein via chip moving reaction boundary electrophoresis,Biosens. Bioelectrons.,2016,77,284-291.
Z. Liu,L. Y. Fan,H. Xiao,* C. X. Cao,* Multiple covalent crosslink soft hydrogels for bioseparation,Chem. Commun. ,2016,52,3247-3250.
R. Zhong,H. Y. Xie,Q. Zhang,S. Jahan,H. Xiao,L. Y. Fan,C. X. Cao,* Enzyme catalysis-electrophoresis titration for multiplex enzymatic assay via moving reaction boundary chip,Lab Chip ,2016,16,3538-3547.
S. Jahan,Q. Zhang,A. Pratush,H. Y. Xie,H. Xiao,L. Y. Fan,C. X. Cao,* In-vial temperature gradient headspace single drop microextraction designed by multi-physics simulation,Anal. Chem.,2016,88,10490–10498.
Y. C. He,F. Z. Kong,L. Y. Fan,J. Y. Wu,X. P. Liu,J. Li,Y. Sun,Q. Zhang,Y. Yang,X. J. Wu,H. Xiao,* C. X. Cao,* Preparation of intact mitochondria using free-flow isoelectri c focusing with post-pH gradient sample injection for morphological,functional and proteomics studies,Anal. Chim. Acta,2017,982,200-208.
Z. Liu,Z. J. Xiao,L. Y. Fan,H. Xiao,* C. X. Cao,* An ionic coordination hybrid hydrogel for bioseparation,Chem. Commun.,2017,53,5842-5845.
W. L. Li,Q. Zhang,H. Kong,X. P. Liu,M. I. Khan,A. Wahid,S. Saud,Hua Xiao,C. X Cao,* L. Y. Fan,* A simple chip electrophoresis titration of neutralization boundary with EDTA photocatalysis for distance-based sensing of melamine in dairy product,Anal.Chem.,2018,90,6710-6717.
X. Y. Cao,F. Z. Kong,Q. Zhang,W. W. Liu,X. P. Liu,G. Q. Li,R. Zhong,L. Y. Fan,* H. Xiao,C. X. Cao,* iPhone-imaged and cell-powered electrophoresis titration chip for the alkaline phosphatase assay in serum by the moving reaction boundary,Lab Chip,2018,18,1758-1766.
F. Z. Kong,S. Jahan,R. Zhong,X. Y. Cao,W. L. Li,Y. X. Wang*,H. Xiao,W. W. Liu*,C. X. Cao*,Electrophoresis titration model of a moving redox boundary chip for a point-of-care test of an enzyme-linked immunosorbent assay,ACS Sens.,2019,4,126–133.
M. I. Khan,Q. Zhang,S. Saud,S. R. Liu,Y. X. Wang,H. Kong,C. H. Wang,A. Uzzaman,L. Y. Fan,H. Xiao,C. X. Cao*,Portable electrophoresis titration chip model for sensing of uric acid in urine and blood by moving reaction boundary,Sens. Actuats. B,2019,286,9-15.
C. H. Wang,Q. Zhang,X. P. Liu,G. Q. Li,H. Kong,M. I. Khan,H. Xiao,Y. X. Wang*,W. W. Liu*,C. X. Cao*,Double inner standard plot model of electrophoresis titration chip for portable and green protein content assay of milk,Lab Chip,2019,19,484–492.
Q. Zhang,W. W. Liu,M. Idrees Khan,C. H. Wang,G. Q. Li,H. Xiao,Y. X. Wang,* C. X. Cao,* Facile Counting of Ligands Capped on Nanoparticles via a Titration Chip of Moving Reaction Boundary Electrophoresis,Anal. Chem.,2019,91,7500-7504.
H. Kong,W. W. Liu,W. Zhang,Q. Zhang,C. H. Wang,M. I. Khan,Y. X. Wang,* L. Y. Fan,* C. X. Cao,* A Facile,Rapid and Low-cost Electrophoresis Titration of Thrombin by Aptamer-linked Magnetic Nanoparticle and Redox Boundary Chip,ACS App. Mat. Inter.,2019,11,29549-29556.
X. T. Jiang,S. Liu,Y. Zhang,A. Sohai,C. X. Cao,* P. Wang,* H. Xiao,* Free-flow Isoelectric Focusing for Comprehensive Separation and Analysis of Human Salivary Microbiome for Lung Cancer,Anal. Chem.,2020,92,12017-12025.
X. J. Wu,Q. H. Meng,Q. Zhang,L. Y. Fan,* H. Xiao,C. X. Cao*,Fluorescent Speed Sensing Model and Boronic Complex Probe for Glycoprotein Assay via a Supramolecular Boundary Electrophoresis,Sens. Actuats. B,2020,309,127773.
L. Chen,Q. Zhang,W. W. Liu,H. Xiao,X. P. Liu,L. Y. Fan,Y. X. Wang,H. G. Li,* C. X. Cao,* Facile and sensitive miRNA electrophoresis titration of moving reaction boundary chip with label-free non-enzymatic amplification,Biosens. Bioelectrons.,2020,170,112676.